CAERULOMYCIN, A NEW ANTIBIOTIC FROM STREPTOMYCES CAERULEUS BALDACCI: I. PRODUCTION, ISOLATION, ASSAY, AND BIOLOGICAL PROPERTIES

Abstract

Streplomyces caeruleus has been shown to produce a hitherto unknown antibiotic to which the name caerulomycin has been given. This was first obtained from a fresh isolate (PRL 1687), and subsequently, after the strain had been identified, from an authentic culture of S. caeruleus. It was extracted from culture filtrates with ether and purified as a colorless crystalline amphoteric substance, C 12 H 11 O 2 N 3 , which inhibited the growth of some filamentous fungi and yeasts and had weak activity against certain bacteria.