<i>In vitro–in vivo</i> correlations for drugs eliminated by glucuronidation: Investigations with the model substrate zidovudine

Abstract

AZT glucuronidation kinetics by human liver microsomes are markedly dependent on incubation conditions, and there is a need for interlaboratory standardization. Extrapolation of in vitro CLint underestimates in vivo hepatic clearance of drugs eliminated by glucuronidation.