In-vitro activity of seventeen antimicrobial compounds against seven species of mycobacteria

Abstract

Within attainable serum concentrations, quinolones, especially ciprofloxacin, inhibited strains of Mycobacterium tuberculosis, M. xenopi, M. kansasii, M. fortuitum and M. marinum; vancomycin inhibited M. tuberculosis, the M. avium-intracellulare-scrofulaceum complex. M. kansasii, M. xenopi and M. chelonei; erythromycin was active against M. kansasii, M. xenopi and M. fortuitum, minocycline against M. kansasii and M. marinum and netilmicin and cefuroxime against M. xenopi. Aztreonam showed some activity against M. tuberculosis but little or no effect was shown by five cephalosporins or imipenem.