Enantioselective rhodium-catalyzed arylation of electron-deficient alkenylarenes

Abstract

β-Substituted alkenyl-para-nitroarenes, an unexplored substrate class for catalytic asymmetric addition reactions, undergo highly enantioselective rhodium-catalyzed arylations with arylboronic acids in the presence of a dibenzylamide-containing chiral diene ligand. One example of the asymmetric arylation of an alkenyl-p-cyano-m-(trifluoromethyl)benzene is also presented.