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Growth Hormone-Like Activity in Hypophysectomized Rats Implanted with Spirometra Mansonoides Spargana
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1970
Year
Growth Hormone-like ActivityHuman GrowthOsteoporosisOrthopaedic SurgeryReproductive EndocrinologyPituitary GlandOsteoarthritisHealth SciencesAnimal PhysiologyMechanobiologyHypophysectomized Rats ImplantedGrowth HormoneEndocrinologyPharmacologyBone MetabolismTibial Cartilage WidthPhysiologySubcutaneous ImplantationMedicineSpirometra Mansonoides Spargana
The subcutaneous implantation of Spirometra mansonoides spargana into hypophysectomized rats produced a striking increase in body weight and tibial cartilage width comparable to that noted with growth hormone. Other tissue responses confirmed this similarity. Injection of plasma from implanted rats also produced a growth hormone-like response including a stimulation of the uptake of 35SO42- by costal cartilage.