Subjective and physiological responses among racemic‐methadone maintenance patients in relation to relative (S)‐ <i>vs.</i> (R)‐methadone exposure

Abstract

These findings agree with previous evidence that (S)-methadone is associated with a significant and potentially adverse profile of responses distinct from that of (R)-methadone. Individual variability in relative (S)- vs. (R)-methadone exposure may be associated with variability in response to rac-methadone maintenance treatment.