Direct chromatographic separation of 2‐arylpropionic acid enantiomers using tris(3,5‐dimethylphenylcarbamate)s of cellulose and amylose as chiral stationary phases

Abstract

Abstract Direct optical resolution of antiinflammatory drugs such as ibuprofen, ketoprofen, flurbiprofen, and tiaprofenic acid were attempted by high‐performance liquid chromatography using tris(3,5‐dimethylphenylcarbamate)s of cellulose and amylose as chiral stationary phases. Although ibuprofen was not sufficiently resolved, the other three 2‐arylpropionic acids were completely resolved by amylose tris(3,5‐dimethylphenylcarbamate). Ibuprofen was resolved as anilide derivative.