Infection and Immunity · 2006 · 271 citations · 43 references
AgriculturePoultry ScienceVeterinary MicrobiologyPoultry MedicinePoultry MicrobiologyPoultry PathologyBacterial Diseases Of PoultryPoultry BacteriologyPoultry Gastrointestinal DiseasesPoultry Infectious DiseasesPoultry NecropsyClostridial Enteric DiseaseClostridium Perfringens InfectionClostridium Perfringens SporesInfectious EnteritisPathogenesis Of Bacterial InfectionsPathogenesis Of Enteric DiseasePathology Of Bacterial InfectionsPoultry-associated Pathogens
The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.
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Milena M. Awad, Amy E. Bryant, Dennis L. Stevens et al. · Molecular Microbiology · 1995 · 312 citations