Generation of Highly Enantioenriched Crystalline Products in Reversible Asymmetric Reactions with Racemic or Achiral Catalysts

Abstract

Backwards is better: By combining forward and backward reaction steps of a reversible chemical process (see scheme) with the physical processes of crystallization, crystal crushing, and dissolution, asymmetric amplification up to 100 % ee can be achieved in the presence of racemic or achiral catalysts starting from a conglomerate of the reaction product 1 with a low enantiomeric excess.