Controlling Cell Adhesion to Titanium: Functionalization of Poly[oligo(ethylene glycol)methacrylate] Brushes with Cell‐Adhesive Peptides

Abstract

A monolayer of 11-(2-bromo-2-methyl)propionyloxy)undecenyldimethylchlorosilane on titanium serves as an initiator for surface-initiated atom-transfer polymerization of (oligoethylene glycol) methacrylate (OEGMA) to prepare poly(OEGMA) brushes. The polymer brush affords resistance to adhesion of osteoblastic cells. Treatment of the brush-modified surface with 4-nitrophenyl chloroformate followed by a GFOGER-containing peptide promotes cell adhesion, thereby representing a strategy to impart biofunctionality to titanium (see figure) and thereby promote osseointegration. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2007/c2129_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.