Brain-Derived Neurotrophic Factor Enhances the Excitability of Small-Diameter Trigeminal Ganglion Neurons Projecting to the Trigeminal Nucleus Interpolaris/Caudalis Transition Zone following Masseter Muscle Inflammation

Abstract

The present study provided evidence that BDNF enhances the excitability of the small-diameter TRG neurons projecting onto the Vi/Vc following MM inflammation. These findings suggest that ganglionic BDNF-trkB signaling is a therapeutic target for the treatment of trigeminal inflammatory hyperalgesia.