Rhodium‐Catalyzed Asymmetric Hydroformylation of <i>N</i>‐Allylamides: Highly Enantioselective Approach to β²‐Amino Aldehydes

Abstract

You′re having a lahf! The asymmetric hydroformylation (AHF) of allylic compounds, catalyzed by a rhodium–yanphos complex, is a direct and concise route to β2-amino aldehydes, acids, and alcohols with excellent enantioselectivity (see scheme; TON=turnover number, acac=acetylacetonate).