Gut · 1986 · 154 citations · 24 references
Life SciencesInfectious DiseasesPathobiologyMucosal ImmunologyToxicodynamicsToxicologic PathologyBacterial ToxinsInfectious DiarrheaIntestinal Barrier FunctionMechanisms Of Toxic InjuryTissue DamageToxin-mediated DiseaseEnterotoxin-mediated DiseaseInflammatory Tissue DamageMembrane Permeability ChangesMucosal Tissue DamagePermeability ChangesTissue Damage MechanismsToxin IsolationToxin-mediated Mucosal Injury
The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.
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Identification of Clostridium difficile as a cause of pseudomembranous colitis.
R.H. George, J Symonds, F Dimock et al. · BMJ · 1978 · 460 citations · Full text
Biological activities of toxins A and B of Clostridium difficile
David M. Lyerly, Donald Lockwood, S H Richardson et al. · Infection and Immunity · 1982 · 260 citations · Full text