Journal of Nuclear Medicine · 2007 · 131 citations · 17 references
MedicineOncologyRadiologyDiagnostic ImagingDiagnostic RadiologyOncologic ImagingBreast Cancer ImagingCancer StagingLymph Node MetastasisSentinel Lymph Node ImagingSentinel Lymph Node MappingTumor DetectionBreast Cancer Sentinel Node MappingLymphatic Drainage MappingLymphatic Metastasis ImagingPlanar Sentinel Node ScintigraphyRadiotracer-based Sentinel Node ImagingRegional Lymphatic DrainageSentinel Lymph Node ScintigraphySentinel Nodes
SPECT/CT fuses SPECT’s functional data with CT’s anatomical detail into a single image. This pilot study evaluated whether SPECT/CT provides additional value for breast cancer and melanoma patients with inconclusive planar lymphoscintigraphy. SPECT/CT was performed immediately after delayed planar imaging, revealing six extra sentinel nodes in four patients, two of which were tumor‑positive and prompted upstaging and tailored management in 5 % of cases. SPECT/CT identified sentinel nodes in patients with negative or ambiguous planar scans, adding nodes and improving localization, and led to upstaging in 5 % of patients.
The recently introduced SPECT/CT integrates the physiologic data of SPECT with the anatomic data of CT into a single image. The purpose of this pilot study was to explore the additional value of SPECT/CT in breast cancer patients and melanoma patients with inconclusive planar image findings.Thirty-one patients had planar lymphoscintigrams showing unexpected lymphatic drainage, 6 had lymphoscintigrams that were difficult to interpret, and 3 showed no drainage on planar imaging. SPECT/CT was performed immediately after delayed planar imaging.In 4 patients, SPECT/CT showed 6 additional sentinel nodes, of which 2 were tumor-positive and led to upstaging and tailored management in 5% of patients. SPECT/CT depicted sentinel nodes in 3 patients whose delayed planar imaging had shown no drainage.SPECT/CT was of additional value in finding the exact anatomic location of sentinel nodes in patients with inconclusive planar image findings. SPECT/CT also detected sentinel nodes in addition to those found on planar images, and SPECT/CT detected sentinel nodes in patients whose planar images had shown none.
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Lymphoscintigraphy for sentinel node mapping using a hybrid SPECT/CT system.
Einat Even‐Sapir, Hedva Lerman, Genady Lievshitz et al. · PubMed · 2003 · 241 citations
Description of a prototype emission-transmission computed tomography imaging system.
Thomas Lang, B.H. Hasegawa, Soo Chin Liew et al. · PubMed · 1992 · 175 citations