Cytotoxicity study of pyrazole derivatives

Abstract

Pyrazolone heterocyclic compound, 3-methyl-1-phenyl-2-pyrazoline-5-one 2(a) was synthesized by condensation reaction between ethyl acetoacetate and phenyl hydrazine and was converted into their corresponding heterocyclic derivatives 2(b) to 2(f2) . Their cytotoxicity effects were measured by brine shrimp lethality bioassay. Among them the compounds 2(b) , 2(f1) , and 2(f2) were highly active according to IC50 values 19.50, 19.50 and 20 ppm respectively. The rest of compounds 2(a) , 2(c) , 2(d1) , and 2(d2) having IC50 values 38, 33.50, 37.50, 36, 37.50 and 36 ppm in that order, were moderately active.