INCREASED FREQUENCY OF ACUTE LOCAL REACTION TO INTRA-ARTICULAR HYLAN GF-20 (SYNVISC) IN PATIENTS RECEIVING MORE THAN ONE COURSE OF TREATMENT

Abstract

The present study suggests that it may be reasonable to counsel patients who have been treated with a course of hylan GF-20 and who desire an additional course that the likelihood of a painful acute local reaction to the medication appears to be increased. Additional study of the frequency of acute local reactions following repeated courses of hylan GF-20 and investigation of the mechanisms of those reactions are warranted.