Simian papovavirus 40 transformation of cells from cancer patient with XY-XXY mosaic Klinefelter's syndrome.

Abstract

Summary Transformation frequency by simian papovavirus 40 of fibroblasts from a lung cancer patient with Klinefelter9s syndrome and XY/XXY mosaicism was 3 to 10 times higher than that of fibroblasts from individuals with normal karyotypes and no history of cancer. The patient9s XXY cell strain also manifested a 3-fold increase in susceptibility to transformation as compared to his XY cell strain. This observation, coupled with the finding of a high frequency of sex chromatin-positive cells in his tumor, could indicate origin of the tumor from the aneuploid cell population.