Palladium(II)‐Catalyzed Regioselective Direct C2 Alkenylation of Indoles and Pyrroles Assisted by the <i>N</i>‐(2‐Pyridyl)sulfonyl Protecting Group

Abstract

Easy on, easy off: The N-(2-pyridyl)sulfonyl group controls the direct PdII-catalyzed alkenylation of indoles, affording the corresponding products in good yields and with complete regiocontrol at C2 (see scheme, DMA=dimethylacetamide). The protocol was also extended to pyrrole derivatives. The final reductive desulfonylation affords the C2-substituted indoles and pyrroles in good yields. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.