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Protecting Group Free Formal Total Synthesis of the Antitubercular Agent Erogorgiaene
14
Citations
22
References
2011
Year
Medicinal ChemistryGroup Free StrategyTempo‐baib‐mediated OxidationEngineeringNatural Product SynthesisDiversity Oriented SynthesisNatural SciencesDiversity-oriented SynthesisSynthetic BiologyOrganic ChemistryPharmacologyInhibitory ActivityEnantioselective SynthesisBiomolecular EngineeringAntitubercular Agent Erogorgiaene
Abstract The formal total synthesis of the antitubercular agent erogorgiaene was achieved in 12 steps by using a protecting group free strategy. The synthesis involves an enamine‐mediated 1,4‐addition, an aldol condensation, dehydrogenation, Wittig olefination, intramolecular Friedel–Crafts cyclization, TEMPO‐BAIB‐mediated oxidation, and Evans auxiliary based diastereoselective methylation.
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