Concepedia

Hemodynamic Activation of β-Catenin and T-Cell-Specific Transcription Factor Signaling in Vascular Endothelium Regulates Fibronectin Expression

Bradley D. Gelfand, Julia Meller, Andrew Pryor, Michaël Kahn, Pamela D. Schoppee Bortz, Brian R. Wamhoff, Brett R. Blackman

Arteriosclerosis Thrombosis and Vascular Biology · 2011 · 66 citations · 53 references

DOIFull text

Open access

Abstract

These data reveal novel constitutive activation of the endothelial β-catenin/TCF signaling pathway in atherosclerosis and regulation of fibronectin through hemodynamic shear stress.

References

53

Hemodynamic Shear Stress and Its Role in Atherosclerosis

Adel M. Malek · JAMA · 1999 · 3.5K citations

, , +17

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions

Robert E. Gerszten, Eduardo A. García‐Zepeda, Yaw-Chyn Lim et al. · Nature · 1999 · 1.2K citations

, , +12

A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription

Katayoon H. Emami, Cu Nguyen, Hong Ma et al. · Proceedings of the National Academy of Sciences · 2004 · 857 citations · Full text

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation

Lilia Topol, Xueyuan Jiang, Hosoon Choi et al. · The Journal of Cell Biology · 2003 · 718 citations · Full text

, , +14

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature

Guohao Dai, Mohammad R. K. Mofrad, Sripriya Natarajan et al. · Proceedings of the National Academy of Sciences · 2004 · 662 citations · Full text

, , +16