Prevalence and Determinant Factors of Sarcopenia in Patients With Type 2 Diabetes

TLDR

These characteristics may contribute to physical disability and metabolic disorders in older adults with diabetes. The study examined the prevalence of sarcopenia in Korean type 2 diabetes patients and compared body composition with non‑diabetic controls. The Korean Sarcopenic Obesity Study assessed 810 participants (414 with diabetes, 396 controls) via dual‑energy X‑ray absorptiometry, defining sarcopenia by skeletal muscle index. Sarcopenia prevalence was 15.7 % in diabetic patients versus 6.9 % in controls, with lower SMI values and a significant independent association between type 2 diabetes and sarcopenia, indicating an elevated risk.

Abstract

OBJECTIVE We examined prevalence of sarcopenia in Korean patients with type 2 diabetes and compared body compositional parameters between subjects with and without type 2 diabetes. RESEARCH DESIGN AND METHODS The Korean Sarcopenic Obesity Study (KSOS) included 810 subjects (414 patients with diabetes and 396 control subjects) who were examined using dual-energy X-ray absorptiometry. Prevalence of sarcopenia was defined using the skeletal muscle index (SMI). RESULTS Prevalence in patients with diabetes and in the control group was 15.7 and 6.9%, respectively. In both men and women, SMI values were significantly decreased in patients with diabetes compared with subjects without diabetes. Furthermore, multiple logistic regression analysis showed that type 2 diabetes was independently associated with sarcopenia. CONCLUSIONS Type 2 diabetes was associated with increased risk of sarcopenia. These characteristics may contribute to physical disability and metabolic disorders in older adults with diabetes.