Modulation of Fatty Acid and Bile Acid Metabolism By Peroxisome Proliferator-Activated Receptor<i>α</i>Protects Against Alcoholic Liver Disease

Abstract

These observations indicate that PPARα plays a protective role to enhance mitochondrial function in response to chronic alcohol consumption by adaptive transcriptional activation and suggest that activation of this nuclear receptor may be of therapeutic value in the treatment for ALD.