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Platinum(II) Complexes of Dipyridophenazine as Metallointercalators for DNA and Potent Cytotoxic Agents against Carcinoma Cell Lines
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1999
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EngineeringMolecular BiologyChemistryInorganic CompoundMedicinal ChemistryDna Base PairAnti-cancer AgentInorganic ChemistryCarcinoma Cell LinesDna ReplicationPhysical ChemistryTumor TargetingPharmacologyInorganic SynthesisNatural SciencesCoordination ComplexPotent Cytotoxic AgentsNew ClassMolecular ComplexDrug DiscoveryDna-intercalating Platinum
A new class of DNA-intercalating platinum(II) complexes has been developed. Their spectroscopic properties, interactions with DNA, and cytotoxicities were studied. [Pt(dppz)(tNC)]CF3SO3 interacts with DNA through intercalation. An emission at 650 nm was observed and ascribed to exciplex formation between the DNA base pair and [Pt(dppz)(tNC)]+ in the excited state.