Disease Markers · 2004 · 10 citations · 18 references
Life SciencesGeneticsMolecular GeneticsHuman GeneticsImmunogeneticsRheumatologyAutoimmune Disease Susceptibility GenesGenetic SusceptibilityGenetic Susceptibility To AutoimmunityManganese MetabolismPsoriatic ArthritisGenotype Frequency EstimationManganese Superoxide DismutasePrecipitating Factor AssessmentPrecipitating Factor IdentificationPsoriasis ImmunopathologyPsoriatic Disease
The purpose of the present study is to investigate the role of manganese superoxide dismutase (MnSOD) gene polymorphisms in the susceptibility to psoriatic arthritis. MnSOD gene polymorphisms were determined by polymerase chain reaction/restriction fragment length polymorphisms method in fifty-two patients with psoriatic arthritis and 90 healthy controls.The genotype frequency of MnSOD 1183C/T was significantly higher in patients with psoriatic arthritis than in controls. In contrast, the frequency of MnSOD 1183T/T was significantly decreased in patients with psoriatic arthritis. The phenotype frequency of MnSOD 1183C was significantly increased in patients with psoriatics arthritis in comparison to healthy controls.Therefore, MnSOD 1183C polymorphisms may be a precipitating factor for the development of psoriatic arthritis.
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Keisuke Hirai, Gjumrakch Aliev, Akihiko Nunomura et al. · Journal of Neuroscience · 2001 · 1.4K citations · Full text
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