Carriers versus Adapters in Stochastic Sensing

Abstract

The perfect host: The detection of analyte-dependent changes in the conduction of individual transmembrane protein pores is demonstrated for small organic molecules, which are detected as complexes with a carrier molecule, cucurbit[6]uril (CB6). The carrier system also allows the determination of dissociation constants, and association and dissociation rate constants, for CB6⋅guest pairs (see picture; αHL=α-hemolysin, THF=tetrahydrofuran).