Anoctamin-1 Cl⁻ Channels in Nociception: Activation by an <i>N</i>-Aroylaminothiazole and Capsaicin and Inhibition by T16A[inh]-A01

Abstract

An ANO1-activator (E-act) induced [Cl(-)]i-dependent sensory neuronal action potentials and mouse nocifensive behaviors; thus, direct ANO1 activation can induce pain perception. ANO1-inhibition attenuated capsaicin-triggering of action potentials and capsaicin-induced nocifensive behaviors. These results indicate ANO1 channels are involved with TRPV1 actions in sensory neurons and inhibition of ANO1 could be a novel means of inducing analgesia.