An Efficient Synthesis of the Piperazinone Fragment of Pseudotheonamide A1 <i>via</i> a Stereoselective Intramolecular Michael Ring Closure

Abstract

Abstract The stereoselective intramolecular Michael ring closure of the dipeptide efficiently gives the piperazinone fragment of pseudotheonamide A1, a serine protease inhibitor from the marine sponge Theonella swinhoei.