Asymmetric synthesis of pyridylethanols and amino alcohols by enantioselective reduction with lithium borohydride modified with N,N′-dibenzoylcystine

Abstract

Optically active 1-pyridylethanols and β- and γ-amino alcohols are obtained in high enantiomeric excess from the enantioselective reduction of acetylpyridines and amino ketones using lithium borohydride, N,N′-dibenzoylcystine, and ethanol.