Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. - Concepedia

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Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis.

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2008

Year

Prabha Ranganathan, Robert Culverhouse, Sharon Marsh, Ami Mody, Tiffany Scott-Horton, Richard Brasington, Amy Joseph, Virginia Reddy, Seth A. Eisen, Howard L. McLeod

Abstract

In addition to SNP in folate-dependent genes, MTX transporter gene SNP may be important markers of MTX toxicity in RA. Such pharmacogenetic associations are race-specific.