Increased Adhesion Molecule and Chemokine Receptor Expression on CD8⁺T Cells Trafficking to Cerebrospinal Fluid in HIV‐1 Infection

Abstract

These findings suggest that LFA-1, CCR5 and CXCR3, and IP-10 play an important role in lymphocyte trafficking to CSF during HIV-1 infection. These observations suggest a "push-pull" model, in which lymphocyte extravasation is driven by lymphocyte activation, expression of adhesion molecules, and increased vascular permeability and is coupled with chemokine-mediated trafficking to inflammatory sites in the CNS.