Infection Control and Hospital Epidemiology · 1998 · 15 citations · 6 references
Public HealthImmunologyInfectious DiseasesHiv PreventionInfection PreventionInfectious Disease PharmacotherapyAntiretroviral TherapyAntiviral TherapyHiv EpidemiologyOccupational Exposure PreventionPost-exposure ProphylaxisHiv Postexposure ProphylaxisHiv Preexposure ProphylaxisProtease Inhibitors
Recent evidence demonstrating the efficacy of zidovudine, as well as experience with protease inhibitors, led to revision of recommendations for occupational exposures to human immunodeficiency virus-infected blood. At our hospital, this resulted in significant increases in rates of reported exposures and prophylaxis initiation. Among 10 healthcare workers given three-drug, protease-inhibitor-containing regimens, five completed 4 weeks, two completed 4 weeks of two drugs, and three stopped due to intolerance. Three workers missed work due to side effects.
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