Effects of dexmedetomidine on haemodynamics in patients undergoing laparoscopic cholecystectomy- A comparative study

Abstract

A randomized double blind prospective trial designed to evaluate the efficacy of clonidine in achieving haemodynamic stability in patients undergoing laparoscopic cholecystectomy. Sixty patients, of both sex (31-60 yrs of age) undergoing elective laparoscopic cholecystectomy were randomly allocated equally in one of the two parallel groups: C & P. Group C received clonidine 1.5 µg /kg intravenously over a period of 15 minutes before induction followed by 1 µg/kg /hr by continuous i.v. infusion. Group P received isotonic saline 0.9% in the same volume. Mean arterial pressure and heart rate in Group C was significantly less after intubation and throughout the period of pneumoperitonium. No significant difference in the parameters of recovery was observed between the two groups. Clonidine improves intra and post-operative haemodynamic stability during laparoscopic surgery without prolonging recovery.