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Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

Emanuel P. Rivers, Bryant Nguyen, Suzanne Havstad et al. · New England Journal of Medicine · 2001 · 10.8K citations · Full text

Veterinary Medicine, Immunology, Pharmacotherapy +15

Prospective Trial of Supranormal Values of Survivors as Therapeutic Goals in High-Risk Surgical Patients

William C. Shoemaker, Paul L. Appel, Harry B. Kram et al. · CHEST Journal · 1988 · 1.8K citations

Medicine, Perioperative Medicine, Surgery +11

A Trial of Goal-Oriented Hemodynamic Therapy in Critically Ill Patients

Luciano Gattinoni, Luca Brazzi, Paolo Pelosi et al. · New England Journal of Medicine · 1995 · 1.5K citations · Full text

Medicine, Physiology, Critical Care Cardiology +16

A Randomized Clinical Trial of the Effect of Deliberate Perioperative Increase of Oxygen Delivery on Mortality in High-Risk Surgical Patients

Owen Boyd · JAMA · 1993 · 960 citations

Medicine, Perioperative Medicine, Surgery +14

Effect of Intraoperative Fluid Management on Outcome after Intraabdominal Surgery

Vadim Nisanevich, Itamar Felsenstein, Gidon Almogy et al. · Anesthesiology · 2005 · 870 citations · Full text

Medicine, Perioperative Medicine, Surgery +16