Endocrinology · 1969 · 25 citations · 0 references
Life SciencesEndocrinologyPhysiologyReproductive BiologyReproductive EndocrinologyReproductive PhysiologyGonadal HormonesHormone SecretionMammalian EndocrinologyRodent EndocrinologyRodent ReproductionTesticular FunctionGonadal Hormone AssaysGonadal Hormone SecretionGonadal Hormone TestingTesticular BiochemistryTesticular HormonesTesticular Steroid Hormone ProductionTesticular Steroidogenesis RegulationTestosterone Regulation
In male pseudohermaphrodite rats (Ps) the mean testicular venous testosterone concentration was 1.1 μg/100 ml and increased 4-fold 30 min after HCG administration. By contrast, normal male litter mates (Nl) had a mean level of 4.1 μg/100 ml, which increased 7- fold with HCG. It was estimated that the Nl rats may have had a testosterone secretion rate 8 times that of Ps. The presence of a vagina in the Ps rats suggests that androgen secretion was defective in the fetus. (Endocrinology 84: 435, 1969)