Palladium‐Catalyzed Carbonylative Synthesis of Quinazolinones from 2‐Aminobenzamide and Aryl Bromides

Xiao‐Feng Wu, Lin He, Helfried Neumann, Matthias Beller

Chemistry - A European Journal · 2013 · 136 citations · 45 references

Concepts

Abstract

C from CO! A straightforward procedure for the carbonylative synthesis of quinazolinones from readily available 2-aminobenzamide and aryl bromides has been developed. In the presence of a palladium catalyst, various quinazolinones were produced in moderate to excellent yields. Remarkably, no chromatography was needed for purification (see scheme).

References

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