Concepedia

Modulation of Gonadotropin-Releasing Hormone Pulse Generator Sensitivity to Progesterone Inhibition in Hyperandrogenic Adolescent Girls—Implications for Regulation of Pubertal Maturation

Susan K. Blank, Christopher R. McCartney, Sandhya Chhabra, Kristin D. Helm, Christine A. Eagleson, R. Jeffrey Chang, John C. Marshall

The Journal of Clinical Endocrinology & Metabolism · 2009 · 128 citations · 33 references

DOIFull text

Open access

Abstract

Hyperandrogenism is variably associated with reduced GnRH pulse generator sensitivity to P-mediated slowing during adolescence. In addition to androgen levels, insulin resistance may modulate P sensitivity.

References

33

Variations in pattern of pubertal changes in girls.

W. A. Marshall, J. M. Tanner · Archives of Disease in Childhood · 1969 · 5.8K citations · Full text

, , +6

A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum

Alex Vermeulen, L. Verdonck, Jean‐Marc Kaufman · The Journal of Clinical Endocrinology & Metabolism · 1999 · 3.7K citations

The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population

Ricardo Azziz, Keslie S. Woods, Rosario Reyna et al. · The Journal of Clinical Endocrinology & Metabolism · 2004 · 2.7K citations · Full text

, , +18

The <i>GPR54</i> Gene as a Regulator of Puberty

Stephanie B. Seminara, Sophie Messager, Emmanouella E. Chatzidaki et al. · New England Journal of Medicine · 2003 · 2.5K citations · Full text

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*

Andrea Dunaif · Endocrine Reviews · 1997 · 2.5K citations · Full text

, , +18