Water‐Soluble, Donor–Acceptor Biphenyl Derivatives in the 2‐(<i>o</i>‐Nitrophenyl)propyl Series: Highly Efficient Two‐Photon Uncaging of the Neurotransmitter γ‐Aminobutyric Acid at <i>λ</i>=800 nm

Abstract

Rattling the cage: The two γ-aminobutyric acid (GABA) derivatives 1 and 2 exhibit efficient and rapid (<5×10−6 s) GABA photorelease upon one-photon excitation combined with two-photon uncaging cross-section at λ=800 nm. Compounds 1 and 2 were successfully used for two-photon GABA release in intact brain tissue, thus offering attractive perspectives in chemical neurosciences. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.