JNCI Journal of the National Cancer Institute · 1972 · 65 citations · 0 references
MedicinePharmacologyToxicologyCancer PharmacologyCarcinogenesisTumor PathologyCarcinogenicity AssessmentChemical CarcinogenesisMalignant NeoplasmsRodent OncologyAnimal Model EvaluationCancer Dose-response AssessmentCorrelationMechanisms Of CarcinogenicityMechanisms Of Chemical CarcinogenesisMolecular CarcinogenesisTotal DoseTumor Incidence Analysis
Dose-response relationships for different dosages per administration of a suspension of benzo[α]pyrene (BP) and ferric oxide given intratracheally to Syrian golden hamsters were examined for respiratory carcinogenesis. Each group received 30 weekly instillations. The amounts of BP were 2.0, 1.0, 0.5, and 0.25 mg/dose, all with an equal amount of ferric oxide. A positive correlation was demonstrated between the dose level of individual administrations and the yield of respiratory tumors. Both tumor latency and tumor multiplicity were related to the dose per administration and hence total dose. As previously noted in this animal model, squamous cell carcinomas were the predominant morphologic type, and the most frequently affected site was the bronchi, followed by the trachea.—J Natl Cancer Inst 49: 1199–1204, 1972.