K _ATP Channel Activation Induces Ischemic Preconditioning of the Endothelium in Humans In Vivo

Abstract

Glibenclamide abolishes and diazoxide mimics endothelial IPC in humans. The time course of the effect of glibenclamide suggests involvement of K(ATP) channels as effectors of endothelial IPC in vivo. These data may have implications for understanding the therapeutic role of agents that modulate K(ATP) channel function.