Proximicins A, B, and C—Antitumor Furan Analogues of Netropsin from the Marine Actinomycete <i>Verrucosispora</i> Induce Upregulation of p53 and the Cyclin Kinase Inhibitor p21

Abstract

Drugs from the sea: Three new netropsin-type antibiotics (1–3) with a hitherto unknown furan core structure have been isolated from marine actinomycete strains and their structures elucidated by means of mass spectrometry and 2D NMR spectroscopy. The compounds show antitumor activity and, in contrast to netropsin, they induce upregulation of p53 and the cyclin kinase inhibitor p21. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705295_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.