Proapoptotic protein Siva binds to the muscle protein telethonin in cardiomyocytes during coxsackieviral infection

Abstract

telethonin might be involved in CVB3-mediated cell damage and in the resulting cardiac dysfunction due to the interaction with Siva. We suggest a molecular mechanism through which coxsackieviral infection contributes to the pathogenesis of chronic myocarditis and in particular of acquired forms of DCM.