Concepedia

The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer

D. Sun, Xue Li, Meng Ma, Jing Liu, Yongping Xu, Ling Ye, Helei Hou, Cuihong Wang, Xun Li, Y. Jiang

Japanese Journal of Clinical Oncology · 2015 · 24 citations · 29 references

DOI

Abstract

The expression of miRNA-328 and miRNA-378 in tumor tissues can be used to predict brain metastases in patients with non-small-cell lung cancer. miRNA-328 might promote brain metastases by regulating the expression of protein kinase Cα. However, the mechanisms of miRNA-378 to promote brain metastases should be studied in the future.

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