Cardiovascular effects of zimelidine and other antidepressants in conscious rats

Abstract

Blood pressure, heart rate and electrocardiograms were recorded in conscious rats during intravenous injections of consecutive increasing doses of zimelidine, amitriptyline, clomipramine, desipramine, imipramine, maprotiline, mianserin and nomifensine. The effects of zimelidine were small and indicate a good tolerance for the drug. After repeated oral administration of zimelidine, 80 mumol/kg, for ten days no effects were seen on body weight, heart rate, blood pressure or in the electrocardiograms.