2‐Aminopurine Incorporation Perturbs the Dynamics and Structure of DNA

André Dallmann, Lars Dehmel, Torben Peters, Clemens Mügge, Christian Griesinger, Jennifer Tuma, N. P. Érnsting

Angewandte Chemie International Edition · 2010 · 80 citations · 34 references

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Abstract

Vive la petite différence: 2-Aminopurine (2AP) induces small but detectable perturbations of the DNA helix. More significant are changes in the base-pair dynamics in the vicinity of 2AP. The differences have been characterized in NMR and UV spectroscopic studies on a 13-mer DNA double strand with either adenine (A) or 2AP in a central position.

References

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