Palladium-Catalyzed Intramolecular Selenocarbamoylation of Alkynes with Carbamoselenoates: Formation of α-Alkylidene-β-lactam Framework

Abstract

Pd-catalyzed intramolecular selenocarbamoylation of alkynes leading to alpha-alkylidene-beta-lactams was developed. This reaction can be applied to thiocarbamoylation and to the synthesis of delta- and epsilon-lactams and a cyclobutanone.