Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice

The DNA sequence of human chromosome 21

Masahira Hattori, Asao Fujiyama, Todd D. Taylor et al. · Nature · 2000 · 1.5K citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

A mouse model for Down syndrome exhibits learning and behaviour deficits

Roger H. Reeves, Nicholas G. Irving, Timothy H. Moran et al. · Nature Genetics · 1995 · 914 citations

Life Sciences, Neurobiology, Neuroscience +12

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21

Joseph R. Arron, Monte M. Winslow, Alberto Polleri et al. · Nature · 2006 · 698 citations

Life Sciences, Genetics, Molecular Genetics +11

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

David M. Holtzman, Daniela Santucci, Joshua F. Kilbridge et al. · Proceedings of the National Academy of Sciences · 1996 · 451 citations · Full text

Life Sciences, Genetics, Neuroscience +17

Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse

Laura L. Baxter · Human Molecular Genetics · 2000 · 279 citations · Full text

Life Sciences, Genetics, Neuroscience +17