Asymmetric Organocatalytic Formal Aza‐Michael Addition of Ammonia to Nitroalkenes

Abstract

The formal addition of ammonia to nitroalkenes, affording optically active β-amino nitro compounds in high yields and enantioselectivities, is presented (see scheme). The approach is based on a novel thiourea-catalyzed aza-Michael reaction, by which benzophenone imine serves as a masked ammonia equivalent, which is released by hydrolysis. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.