Atmospheric gas plasmaâinduced ROS production activates TNF-ASK1 pathway for the induction of melanoma cancer cell apoptosis

Abstract

Atmospheric gas plasmas (AGPs) up-regulate intracellular ROS levels and induce apoptosis in melanoma cells. Evidence for TNF-signaling dependence of ASK1-mediated apoptosis suggests possible mechanisms for AGP activation and regulation of apoptosis-signaling pathways in tumor cells.