Rational Design of a Tetrameric Protein to Enhance Interactions between Self‐Assembled Fibers Gives Molecular Hydrogels

Abstract

Styling gels: The fusion protein ULD-TIP-1 (ULD=ubiquitin-like domain, TIP-1=Tax-interacting protein-1) enhances the interactions between self-assembled fibers formed by small molecules bearing a peptide that specifically binds to the ULD-TIP-1. The mechanical properties of the resulting hydrogels (see picture) are tuned by using peptides with different dissociation constants for the protein. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.