The role of genetic factors in patients with hepatocellular carcinoma and iron overload – a prospective series of 234 patients

Abstract

Additional genetic risk factors of IO were found in 18 patients (7.7%) among a large series of 234 HCC patients. Screening for IO and the associated at-risk genotypes in patients who have developed HCC, is useful for both determining etiologic diagnosis and enabling family screening and possibly primary prevention in relatives.